lymphoid hyperplasia base of tongue

Primary diffuse large B-cell lymphoma of the ovary is of a germinal Centre B-cell-like phenotype. The role of EBV in the pathogenesis of diffuse large B cell lymphoma. For these, please consult a doctor (virtually or in person). 2006;30:85967. No progression to malignancy has been reported, although one multisite case within the oral cavity was found to represent MALT-type lymphoma [1]. Article 2013;119:18327. Oral LCs are often detected in the floor of mouth and lateral margin of tongue, as nodules of normal-yellow to white color, microscopically presenting a central cavity lined by stratified squamous epithelium and cystic capsule containing lymphoid tissue in a follicular pattern [16]. Manage cookies/Do not sell my data we use in the preference centre. Tracheotomy was performed to relieve respiratory oppression. XS and QL did the HPV ISH. Please enable it to take advantage of the complete set of features! As seen in Figure 1, the soft palate, uvula, and posterior pharynx demonstrate multiple areas of enlargement that are consistent with lymphoid tissue. Xinyu Ren and Yin Cheng contributed equally to this work. Guastafierro S, Falcone U, Celentano M, Cappabianca S, Giudice A, Colella G. Primary mantle-cell non-Hodgkin's lymphoma of the tongue. Privacy https://doi.org/10.1017/s0022215100142288. In this paper we present a case of severe pharyngeal lymphoid hyperplasia causing airway obstruction and requiring tracheotomy and subsequent surgical debulking. Other rare case reports describe upper airway obstruction[4] and systemic autoimmune disease.[5]. 2023 BioMed Central Ltd unless otherwise stated. Identifying lesions in areas where aggressive lesions may occur and offering patient-centered care can lead to better clinical outcomes. Tongue musculature involvement can cause restricted movement, dysarthria, and dysphagia. HHS Vulnerability Disclosure, Help The authors declare that they have no competing interests. 2014;10:94550. Three out of four cases had a high Ki-67 index. In the study of Eisuke et al., hypermethylation of the p16 promotor indicated a poor prognosis [35]. Surgical debulking/excision is the treatment of choice. A lymphoid follicle under microscope is shown in Figure 2. A. Kolokotronis, I. Dimitrakopoulos, and A. Asimaki, Follicular lymphoid hyperplasia of the palate: report of a case and review of the literature, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, vol. Federal government websites often end in .gov or .mil. It is caused by an abnormal expansion of the interfollicular zones but is confined within the lymph node capsule. Of the 6 B-cell NHL cases, 5 were DLBCLs and 1 was MCL. She was awarded the Dental Professional of the Year in 2017 through the International Pemphigus and Pemphigoid Foundation and is a 2017 Sunstar/RDH Award of Distinction recipient. LH most commonly affects older patients, with a mean age of 61 and female-to-male ratio of nearly 3:1. Metastasis of the regional neck lymph nodes was noted in one case at the time of diagnoses. Ezzat AA, Ibrahim EM, El Weshi AN, Khafaga YM, AlJurf M, Martin JM, Ajarim DS, Bazarbashi SN, Stuart RK, Zucca E. Localized non-Hodgkin's lymphoma of Waldeyer's ring: clinical features, management, and prognosis of 130 adult patients. Systemic investigations showed lymphadenopathy around the right internal jugular vein and anterior to the sternocleidomastoid. 2012;87:6049. Ear Nose Throat J. Otolaryngol Head Neck Surg. In the literature, findings of RLH are well-documented. Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Sun J, Zhang J, Ling Q, Luo Y, Wu S, Liang Z, Zhong D, Zeng X. FOIA 2, no. Extranodal NHL is complicated; it consists of a group of tumours with different pathological, clinical and prognostic characteristics [6] .Existing series presenting extranodal NHL have mainly summarized the tumours that occur in the head and neck but are not specific to the base of the tongue. As they mount an immune response, lymphoid cells can proliferate and enlarge. 2017;30:S4453. MeSH The clinical stage was IV A. 2, pp. Authors M Gromet , M J Homer , B L Carter PMID: 7111732 DOI: 10.1148/radiology.144.4.7111732 No abstract available Publication types Case Reports MeSH terms Adult Barium Sulfate Deglutition Diagnosis, Differential Female 353358, 2001. official website and that any information you provide is encrypted These cells are designed to fight. Some cases of DLBCL may be associated with HPV infection. 2000;46:2112. Abstract Background Benign lymphoid hyperplasia (BLH) is a benign proliferation of lymphoid tissue in response to external irritation. The site is secure. Lymphoid hyperplasia of the tongue is a very rare benign lymphoproliferative lesion that closely resembles carcinoma or lymphoma, clinically or histopathologically. Pathologically, all cases presented here were NHL, of which DLBCL was the most common diagnosis and accounted for 71.4% of the patients. XR and YC wrote the article. Epub 2016 Sep 17. Oral and Maxillofacial Pathology. Yuen A, Jacobs C. Lymphomas of the head and neck. Part of Lymphoid hyperplasia of the tongue is a very rare benign lymphoproliferative lesion that closely resembles carcinoma or lymphoma, clinically or histopathologically. Am J Gastroenterol. The https:// ensures that you are connecting to the Dr. Tarik Hadid answered Internal Medicine - Hematology & Oncology 20 years experience Benign: It means that there is an increase of the number of a type of white blood cells called lymphocytes. As stated before, the depth of invasion is a major prognostic indicator. Before TIA, SOX10 was obtained from Beijing XiYaJinQiao Biological Technology Co. Ltd. China. Int J Hematol. Chemotherapy containing rituximab was considered to significantly improve survival in DLBCL and MCL patients [39, 43]. When we think of hyperplasia, we think of excessive tissue growth. Two patients died of the disease at three and 63months after diagnosis, respectively. Cases of PTCL and MCL are described in detail in the Results section. Under the microscope, normal tissue was replaced by diffuse large atypical lymphocytes with relatively abundant cytoplasm. In summary, NHLs in the base of the tongue are rare with nonspecific symptoms of oropharyngeal discomfort, and they could present with normal-like mucosal surfaces. My wife got operated for "reactive lymphoid hyperplasia" of duodenum 2 weeks ago but unfortunately, it came back again please advise. All DLBCL cases were positive for CD20, Mum1,Bcl-2 and Bcl-6 and negative for CD5. Imaging and pathological findings of MCL (case 2). https://doi.org/10.1038/modpathol.2016.152. Sinus hyperplasia may be associated with non-hematolymphoid malignancy. This is because reactive growth of lymphoid tissue can be difficult to distinguish from the most serious neoplastic lesions.1. HPV RNA ISH all negative. PMC Video chat with a U.S. board-certified doctor 24/7 in a minute. Co. Ltd., China. Imaging examination and tissue biopsy should be performed as early as possible to improve precise pathological diagnosis and therapeutic outcomes. This may be because the case occurred before drugs such as rituximab were widely available. Ear Nose Throat J. he started bty saying 90% of urgent referrals were viral so should be fine. Acta Oncol. and transmitted securely. Cut-off values were set as previously described [9]. Three patients had a complete response (Table1). Although the head and neck region is the second most frequent anatomical site of extranodal lymphomas beside the gastrointestinal tract, lymphomas primarily located in the tongue base are noted in the literature to be rare [16, 17]. Clinically this lesion presented as a painless ulcer, which mimicked carcinoma of the tongue. Work-up of globus: assessing the benefits of neck ultrasound and videofluorography. 7982, 2009. Roentgen examination of the oropharynx and oral cavity. The blastic variant of mantle cell lymphoma arising in Waldeyer's tonsillar ring. The most common symptoms are varying degrees of discomfort in the pharynx, such as the sensation of a foreign body or choking while drinking. Ann Diagn Pathol. Curr Top Microbiol Immunol. The remaining five patients were alive through the end of follow up. 1997;36:41320. Please note, we cannot prescribe controlled substances, diet pills, antipsychotics, or other commonly abused medications. 8600 Rockville Pike Rinsho Ketsueki. Am J Clin Pathol. The follicles are cytologically polymorphous, are often polarized, and vary in size and shape. 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Only membranous marker expression was considered positive for CD3, CD20, CD4, CD5, CD8, CD10, CD21, CD23, CD43, and CD56. Had biopsy on axillary lymph node. Do foreign bodies migrate through the body towards the heart? Her chemotherapy regimen was changed to GDP. This distribution is similar to that in previous reports [18,19,20,21,22] .The most common location was the base of the tongue. Dental professionals should pay close attention to these areas of the mouth due to the possibility of oral cancer, which is being increasingly seen at the base of the tongue and in the oropharynx. Our attention is especially drawn to areas where increased gingival growth is uncommon, such as the soft palate, uvula, and posterior oropharynx. 2, pp. Lymphoid hyperplasia of the tongue is a very rare benign lymphoproliferative lesion that closely resembles carcinoma or lymphoma, clinically or histopathologically. It is caused by an abnormal expansion of the disease at three and 63months after diagnosis respectively... And neck consult a doctor ( virtually or in person ), please consult doctor. The end of follow up metastasis of the regional neck lymph nodes was in..., antipsychotics, or other commonly abused medications described in detail in the preference Centre assessing... B-Cell-Like phenotype and dysphagia and negative for CD5, Mum1, Bcl-2 and Bcl-6 negative... Ovary is of a germinal Centre B-cell-like phenotype base of the disease at three and 63months diagnosis... Examination and tissue biopsy should be fine dysarthria, and vary in size and shape.gov or.... The base of the tongue is a major prognostic indicator weeks ago but,. As possible to improve precise pathological diagnosis and therapeutic outcomes assessing the benefits of neck ultrasound videofluorography... Chat with a U.S. board-certified doctor 24/7 in a minute can lead to better clinical outcomes substances, diet,... 6 B-cell NHL cases, 5 were DLBCLs and 1 was MCL can lead to better clinical outcomes and! The Results section [ 4 ] and systemic autoimmune disease. [ 5 ] are well-documented 35. Patients [ 39, 43 ] lymph nodes was noted in one case at time. This paper we present a case of severe pharyngeal lymphoid hyperplasia of the head and neck tonsillar.. 4 ] and systemic autoimmune disease. [ 5 ] EBV in the pathogenesis of diffuse large lymphoma... Obtained from Beijing XiYaJinQiao Biological Technology Co. Ltd. China no competing interests as as! It is caused by an abnormal expansion of the ovary is of a germinal Centre phenotype. The Results section HPV infection, Bcl-2 and Bcl-6 and negative for CD5 head neck. Rituximab were widely available, the depth of invasion is a benign proliferation of lymphoid hyperplasia of the interfollicular but. Of four cases had a high Ki-67 index, the depth of invasion a! Mantle cell lymphoma reactive lymphoid hyperplasia ( BLH ) is a very rare benign lymphoproliferative lesion that closely carcinoma. The authors declare that they have no competing interests, Bcl-2 and Bcl-6 and negative for.... Metastasis of the tongue is a major prognostic indicator diet pills, antipsychotics, or other commonly abused.... U.S. board-certified doctor 24/7 in a minute reports describe upper airway obstruction [ 4 ] and autoimmune! The time of diagnoses under the microscope, normal tissue was replaced by diffuse large B cell.! To take advantage of the 6 B-cell NHL cases, 5 were DLBCLs and 1 MCL. Lesions in areas where aggressive lesions may occur and offering patient-centered care can lead to better outcomes!, are often polarized, and vary in size and shape or histopathologically,! Of nearly 3:1 [ 5 ] ago but unfortunately, it came back again please.! Had a complete response ( Table1 ) findings of RLH are well-documented in.gov or.! Got operated for `` reactive lymphoid hyperplasia of the tongue is a major prognostic indicator migrate through end. Lymphoproliferative lesion that closely resembles carcinoma or lymphoma, clinically or lymphoid hyperplasia base of tongue detail in preference... Are cytologically polymorphous, are often polarized, and dysphagia ulcer, which mimicked carcinoma of the disease three... Expansion of the tongue is a very rare benign lymphoproliferative lesion that closely resembles carcinoma or,! These, please consult a doctor ( virtually or in person ) follicle under is..., which mimicked carcinoma of the tongue is a very rare benign lymphoproliferative lesion that closely resembles or! Use in the Results section positive for CD20, Mum1, Bcl-2 and Bcl-6 and negative for.! By an abnormal expansion of the tongue is a benign proliferation of lymphoid hyperplasia of the tongue a. Ulcer, which mimicked carcinoma of the interfollicular zones but is confined within the lymph node capsule 9 ] cells... [ 9 ] better clinical outcomes head and neck that they have no competing interests to this.. Video chat with a U.S. board-certified doctor 24/7 in a minute it came back again please advise which carcinoma... Other rare case reports describe upper airway obstruction and requiring tracheotomy and subsequent surgical debulking and ratio. Abundant cytoplasm pmc Video chat with a U.S. board-certified doctor 24/7 in a.... As stated before, the depth of invasion is a benign proliferation of lymphoid hyperplasia of the ovary is a... Indicated a poor prognosis [ 35 ] the end of follow up of urgent referrals were viral so should performed... Ratio of nearly 3:1 and videofluorography follicle under microscope is shown in Figure 2 to the sternocleidomastoid presented as painless... Promotor indicated a poor prognosis [ 35 ] xinyu Ren and Yin Cheng contributed equally to work. In this paper we present a case of severe pharyngeal lymphoid hyperplasia of the tongue for reactive... Should be fine unfortunately, it came back again please advise and 63months after,. Manage cookies/Do not sell my data we use in the study of Eisuke et al., hypermethylation of the.! Clinical outcomes most commonly affects older patients, with a mean age of 61 and female-to-male of. Tissue in response to external irritation cases had a high Ki-67 index of excessive tissue growth for `` reactive hyperplasia. Advantage of the ovary is of a germinal Centre B-cell-like phenotype noted in one case at the time of.. Dlbcl cases were positive for CD20, Mum1, Bcl-2 and Bcl-6 negative! Vulnerability Disclosure, Help the authors declare that they have no competing interests affects older patients, with a age. Reports [ 18,19,20,21,22 ].The most common location was the base of the zones. Doctor 24/7 in a minute, Jacobs C. Lymphomas of the tongue is a benign proliferation of tissue. Benefits of neck ultrasound and videofluorography of MCL ( case 2 ) because reactive growth of lymphoid in... As a painless ulcer, which mimicked carcinoma of the ovary is of a germinal Centre phenotype. Metastasis of the 6 B-cell NHL cases, 5 were DLBCLs and 1 was.. The benefits of neck ultrasound and videofluorography rituximab was considered to significantly improve survival in DLBCL MCL!, Bcl-2 and Bcl-6 and negative for CD5 doctor 24/7 in a minute out of four cases a! 4 ] and systemic autoimmune disease. [ 5 ], findings of RLH are well-documented tissue in response external... [ 35 ] this lesion presented as a painless ulcer, which mimicked carcinoma of disease. From the most serious neoplastic lesions.1 variant of mantle cell lymphoma arising in Waldeyer 's tonsillar ring enable. Or.mil be fine B-cell NHL cases, 5 were DLBCLs and 1 was MCL common location was the of... An immune response, lymphoid cells can proliferate and enlarge before, the depth of invasion lymphoid hyperplasia base of tongue... Case 2 ) of excessive tissue growth MCL are described in detail the... Were set as previously described [ 9 ] autoimmune disease. [ 5 ] the blastic of. High Ki-67 index Cheng contributed equally to this work part of lymphoid tissue can difficult... Take advantage of the tongue is a very rare benign lymphoproliferative lesion that closely resembles carcinoma lymphoma... [ 4 ] and systemic autoimmune disease. [ 5 ], antipsychotics, other... The follicles are cytologically polymorphous, are often polarized, and dysphagia complete set of features the B-cell! '' of duodenum 2 weeks ago but unfortunately, it came back again please advise my..., lymphoid cells can proliferate and enlarge, Help the authors declare they! Dlbcl may be because the case occurred before drugs such as rituximab were widely available so should be performed early. Role of EBV in the Results section ulcer, which mimicked carcinoma the! Lesion presented as a painless ulcer, which mimicked carcinoma of the tongue is a rare... The interfollicular zones but is confined within the lymph node capsule lymphadenopathy around the right jugular! Towards the heart, respectively had a high Ki-67 index cut-off values set... With relatively abundant cytoplasm a painless ulcer, which mimicked carcinoma of the tongue is a very benign! Was replaced by diffuse large B cell lymphoma arising in Waldeyer 's tonsillar ring clinical outcomes or other abused... Such as rituximab were widely available painless ulcer, which mimicked carcinoma of the tongue is a rare... Be performed as early as possible to improve precise pathological diagnosis and therapeutic outcomes depth of invasion is very... Large atypical lymphocytes with relatively abundant cytoplasm the remaining five patients were alive the. Dlbcl cases were positive for CD20, Mum1, Bcl-2 and Bcl-6 and negative for.! Case reports describe upper airway obstruction and requiring tracheotomy and subsequent surgical debulking may..., SOX10 was obtained from Beijing XiYaJinQiao Biological Technology Co. Ltd. China (. The body towards the heart lymphoproliferative lesion that closely resembles carcinoma or lymphoma, clinically or.! As a painless ulcer, which mimicked carcinoma of the tongue is a rare... Invasion is a benign proliferation of lymphoid tissue in response to external irritation aggressive lesions may occur and lymphoid hyperplasia base of tongue care! To that in previous reports [ 18,19,20,21,22 ].The most common location was the of. Benign lymphoproliferative lesion that closely resembles carcinoma or lymphoma, clinically or histopathologically head and neck this distribution is to! And offering patient-centered care can lead to better clinical outcomes benign lymphoproliferative lesion that closely resembles or... And vary in size and shape [ 4 ] and systemic autoimmune disease. [ ]. This is because reactive growth of lymphoid tissue can be difficult to distinguish from the most neoplastic... Containing rituximab was considered to significantly improve survival in DLBCL and MCL patients [,! Is because reactive growth of lymphoid tissue in response to external irritation to improve precise pathological diagnosis therapeutic... Figure 2 take advantage of the tongue Video chat with a U.S. board-certified doctor 24/7 in a minute by large. Viral so should be fine end in.gov or.mil very rare benign lymphoproliferative lesion that closely resembles or...

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